Studies on the oral administration of saliva-parotin-A. II. Effects on the epiphyseal growth of tibia in rats.

In the previous paper(Ito et al., 1965), it was described that the oral administration of saliva-parotin-A(abbr. as SPA) caused various biological responses such as the hypocalcemia in rabbits, the promotion of calcification in rabbit incisor dentine and the excretion of potent uro-parotin in sialoadenectomized rabbits. Those responses are recognized as the biological properties of parotin and its relating substances, and it was suggested that the oral administration of SPA would be effective. As the another property of SPA, Yoshimura and Moriwaki (1963) reported that the subcutaneous injection of SPA to the sialoadenectomized rats caused the retardation of the involution in tibial epiphysis though the ability was less than that of parotin. The purpose of the present investigation was to study the effect of SPA administered orally upon the body-weight growth and the histological changes in the tibial epiphysis and in the adrenal of the sialoadenectomized rats.